A Hybrid Model of Sprouting Angiogenesis
Milde F., Bergdorf M., Koumoutsakos P., Lecture Notes in Computer Science, Springer Berlin, 167-176, 2008
We present a computational model of tumor induced sprouting angiogenesis that involves a novel coupling of particle-continuum descriptions. The present 3D model of sprouting angiogenesis accounts for the effect of the extracellular matrix on capillary growth and considers both soluble and matrix-bound growth factors. The results of the simulations emphasize the role of the extracellular matrix and the different VEGF isoforms on branching behavior and the morphology of generated vascular networks.