A Hybrid Model of Sprouting Angiogenesis

Milde F., Bergdorf M., Koumoutsakos P., Lecture Notes in Computer Science, Springer Berlin, 167-176, 2008

We present a computational model of tumor induced sprouting angiogenesis that involves a novel coupling of particle-continuum descriptions. The present 3D model of sprouting angiogenesis accounts for the effect of the extracellular matrix on capillary growth and considers both soluble and matrix-bound growth factors. The results of the simulations emphasize the role of the extracellular matrix and the different VEGF isoforms on branching behavior and the morphology of generated vascular networks.


DOI: 10.1007/978-3-540-69387-1_19