Particle Simulations of Growth: Application to Angiogenesis
Milde F., Bergdorf M., Koumoutsakos P., 2012. Particle Simulations of Growth: Application to Angiogenesis. In: Jackson T.L., editor. Modeling Tumor Vasculature. Springer New York. pages 305-334.
We apply the particle-based framework developed in the previous chapter to develop continuum and discrete-continuum models of sprouting angiogenesis under consideration of a detailed tumor microenvironment. We present results on the vessel development as a function of the extracellular matrix and different VEGF isoforms.