Tumor Induced Angiogenesis
Tumor induced sprouting angiogenesis is the process of new capillary growth from an existing vasculature, induced by tumor cells that have the “angiogenic switch” turned on. Vascular endothelial growth factors(VEGF) released by tumor cells diffuse through the extracellular Matrix and stimulate endothelial cells lining existing vessels in the proximity of the tumor to form sprouts. As the newly formed sprout tips migrate through the ECM, deﬁning the morphology of the dgradients determine their migration paths.
Simulation of blood vessel growth (red) in the presence of matrix-bound VEGF (blue)
A 3D Model of Sprouting Angiogenesis:
We have developed a novel model of sprouting angiogenesis that quantifies several biological assumptions and their dynamic interactions. This enables the identification of critical factors in the process of angiogenesis and paving the way for future integration of experimental data.
The implementation of this model allows for a large scale parametric study of blood vessel morphology as inﬂuenced the structure of the ECM, the distribution of matrix-bound VEGF and the intensity of cell-cell and cell-matrix adhesion.
People: Florian Milde, Michael Bergdorf
- Milde F., Bergdorf M., Koumoutsakos P., A Hybrid Model for 3D Simulations of Sprouting Angiogenesis, Biophysical J., 95, 3146–3160, 2008 (Abstract) (pdf)
- Milde F., Bergdorf M., Koumoutsakos P., A Hybrid Model of Sprouting Angiogenesis, Lecture Notes in Computer Science, 167-176, Springer Berlin, 2008 (Abstract) (pdf)